• 研究组主要研究兴趣及方向：

放射肿瘤学、肿瘤学、影像医学与核医学

• 研究内容：

1. 肿瘤质子治疗

2. 肿瘤精准放疗研究

3. 肿瘤放射免疫的临床和基础研究

4. 分子功能影像指导肿瘤精准诊疗的临床和基础研究

5. 基于人工智能、基因和蛋白组学技术的肿瘤放疗疗效和毒性预测研究

• 个人简况：

1. 导师类型：科学学位博士生导师

2. 专业技术职称：主任医师、教授

3. 行政职务：中国科学技术大学附属第一医院(安徽省立医院）副院长、中国科学技术大学附属第一医院西区(安徽省肿瘤医院）院长

4. 招生专业：肿瘤学

5. 简介：

 ①学术任职情况：

中国医师协会肿瘤多学科诊疗专委会副主任委员；世界华人医师协会肿瘤放射治疗分会主任委员；中国肿瘤放射治疗联盟执行主任委员；中华医学会肿瘤放射治疗分会青委会副主任委员；中国抗癌协会肺癌专委会、放射防护专委会常务委员；中国临床肿瘤学会非小细胞肺癌专委会常务委员等。《Nat Commun》、《Int J Radiat Oncol Biol Phys》、《J Nucl Med》、《BMC Medicine》、《Eur J Nucl Med Mol I》等杂志审稿人，《肿瘤综合治疗电子杂志》、《J Cancer Res Ther》等杂志编委。

 ②个人教育及工作经历：

教育经历

1992年9月-1995年7月，张家口医学院，临床医学

2000年9月-2003年6月，江西医学院，生理学，硕士

2004年9月-2007年6月，天津医科大学，肿瘤学，博士

2008年11月-2010年12月，美国密西根大学，放射肿瘤学，博士后

工作经历

1995年10月-2000年8月，河北省衡水市友谊医院肿瘤科

1996年9月-1997年9月，北京大学肿瘤医院肿瘤内科 进修

2002年8月-2003年2月，天津医科大学肿瘤医院乳腺外科 进修

2003年7月-2023年12月，山东省肿瘤医院放疗科 医师

2024年1月-至今，中国科学技术大学生命科学与医学部 教授

2024年2月-至今，中国科学技术大学附属第一医院(安徽省立医院）副院长、中国科学技术大学附属第一医院西区(安徽省肿瘤医院）院长

• 联系方式：

E-mail: yuanshuanghu@sina.com

• 近五年发表重要学术论文：

1. Li L, He K, Zhou T, Xu Y, Pang J, Yu Q, Gao Y, Shi H, Zhu H, Li M, Yu J*, Yuan S*. Recurrence/prognosis estimation using a molecularly positive surgical margin-based model calls for alternative curative strategies in pIIIA/N2 NSCLC. Mol Oncol. 2024 Feb 7.

2. Li L, Duan J, Gao Y, Yin Y, Yang F, Tang W, Song X, Hu T, Cui J, Yu J, Yuan S*. Multi-omics predictive model based on clinical, radiomic and genomic features for predicting the response of limited-stage small cell lung cancer to definitive chemoradiotherapy. Clin Transl Med. 2024 Jan;14(1):e1522.

3. Qiao K, Qin X, Fu S, Ren J, Jia J, Hu X, Tao Y, Yuan S*, Wei Y*. Value of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT for differential diagnosis of malignant and various inflammatory lung lesions: comparison with [¹⁸F]FDG PET/CT. Eur Radiol. 2024 Mar;34(3):1948-1959.

4. Liu J, Yu Q, Wang XS, Shi Q, Wang J, Wang F, Ren S, Jin J, Han B, Zhang W, Su X, Yuan S*, Lin H*. Compound Kushen Injection Reduces Severe Toxicity and Symptom Burden Associated With Curative Radiotherapy in Patients With Lung Cancer. J Natl Compr Canc Netw. 2023 Aug;21(8):821-830.e3.

5. Tao Y, Sun Q, Wei Y, Liang C, Tang S, Li J, Pei J, Li Y, Wang C*, Yuan S*. Early and Accurate Detection of Radiation-induced Heart Damage by Cardiodynamicsgram. J Cardiovasc Transl Res. 2023 Aug 7.

6. He K, Li L, Li A, Xu Y, Pang J, Mu D, Ma J, Ge H, Maleki A, Qin X, Zhang X, Ou Q, Shao Y, Yu J, Yuan S*. Genomic features, evolutionary patterns and minimal residual disease at surgical margins as novel prognostic/predictive biomarkers in locally advanced rectal cancer. Clin Transl Med. 2023 Jun;13(6):e1286.

7. Cui J, Li L, Liu N, Hou W, Dong Y, Yang F, Zhu S, Li J*, Yuan S*. Model integrating CT-based radiomics and genomics for survival prediction in esophageal cancer patients receiving definitive chemoradiotherapy. Biomark Res. 2023 Apr 24;11(1):44.

8. Tao Y, Lu J, Deng W, Ma R, Tang S, Wei Y*, Yuan S*. Correlation of Mean Heart Dose and Cardiac Biomarkers with Electrocardiographic Changes in Patients Receiving Thoracic Radiation Therapy. Radiat Res. 2023 Apr 1;199(4):336-345.

9. Hu X, Zhou T, Ren J, Duan J, Wu H, Liu X, Mu Z, Liu N, Wei Y*, Yuan S*. Response Prediction Using ¹⁸F-FAPI-04 PET/CT in Patients with Esophageal Squamous Cell Carcinoma Treated with Concurrent Chemoradiotherapy. J Nucl Med. 2023 Apr;64(4):625-631.

10. Qin X, Bai Y, Zhou S, Shi H, Liu X, Wang S, Wu X, Pang J, Song X, Fan X, Ou Q, Xu Y, Bao H, Li L, Li J, Shao Y, Yuan S*. Early diagnosis of brain metastases using cerebrospinal fluid cell-free DNA-based breakpoint motif and mutational features in lung cancer. Clin Transl Med. 2023 Mar;13(3):e1221.

11. Li L, Sun J, Liu N, Yu R, Zhang J, Pang J, Ou Q, Yin Y, Cui J, Yao X, Zhao R, Shao Y*, Yuan S*, Yu J*. Clinical Outcome-Related Cancer Pathways and Mutational Signatures in Patients With Unresectable Esophageal Squamous Cell Carcinoma Treated With Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2023 Feb 1;115(2):382-394.

12. Wei Y, Zheng J, Ma L, Liu X, Xu S, Wang S, Pei J, Cheng K*, Yuan S*, Yu J*. [¹⁸F]AlF-NOTA-FAPI-04: FAP-targeting specificity, biodistribution, and PET/CT imaging of various cancers. Eur J Nucl Med Mol Imaging. 2022 Mar 9.     

13. Wei Y, Cheng K, Fu Z, Zheng J, Mu Z, Zhao C, Liu X, Wang S, Yu J*, Yuan S*. [¹⁸F]AlF-NOTA-FAPI-04 PET/CT uptake in metastatic lesions on PET/CT imaging might distinguish different pathological types of lung cancer. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1671-1681.

14. Li L, Zheng J, Liu Z, Huang Y, Xiao J, Wang S, Yu Q, Zhang Q, Hu X, Zhao W, Hou W, Spring Kong FM, Yu J, Yuan S*. Pre-treatment ¹⁸F-RGD Uptake may Predict Adverse Events during Apatinib Antiangiogenic Therapy. Clin Oncol (R Coll Radiol). 2022 Jun;34(6):e238-e245.

15. Jiang A, Ni M, Li L, Zhao F, Yao Y, Ding X, Yu Q, Zhang L, Yuan S*. Upfront brain radiotherapy improves intracranial progression-free survival but not overall survival in lung adenocarcinoma patients with brain metastases: a retrospective, single-institutional analysis from China. J Cancer. 2022 Jan 1;13(2):602-609.

16. Wei Y, Wei C, Chen L, Liu N, Ou Q, Yin JC, Pang J, Fang Z, Wu X, Wang X, Mu D, Shao Y, Yu J*, Yuan S*. Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation. Cancer Res Treat. 2022 Jan 17.  

17. Li L, Tang S, Yin JC, Dong L, Yang Z, Liu Y, Ma J, Chang P, Pang J, Bao H, Mu D, Zheng X, Aishajiang R, He K, Zhang S, Ni M, Wu X, Wang X, Shao Y*, Wang J*, Ge H*, Yu J*, Yuan S*. Comprehensive Next-Generation Sequencing Reveals Novel Predictive Biomarkers of Recurrence and Thoracic Toxicity Risks After Chemoradiation Therapy in Limited Stage Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2022 Apr 1;112(5):1165-1176.

18. Yang F, Zhang J, Zhou L, Xia W, Zhang R, Wei H, Feng J, Zhao X, Jian J, Gao X*, Yuan S*. CT-based radiomics signatures can predict the tumor response of non-small cell lung cancer patients treated with first-line chemotherapy and targeted therapy. Eur Radiol. 2021 Sep 26.

19. Li L, Zhao W, Sun X, Liu N, Zhou Y, Luan X, Gao S, Zhao S, Yu J, Yuan S*. F-18-RGD PET/CT imaging reveals characteristics of angiogenesis in non-small cell lung cancer. Transl Lung Cancer Res. 2020 Aug;9(4):1324-1332.

20. He K, Zhang S, Shao L, Yin J, Wu X, Shao Y, Yuan S*, Yu J*. Developing more sensitive genomic approaches to detect radioresponse in precision radiation oncology: From tissue DNA analysis to circulating tumor DNA. Cancer Lett. 2020 Mar 1;472:108-118.

21. Zeng H, Li R, Hu C, Qiu G, Ge H, Yu H, Zhang K, Hu M, Zeng P, Xiao D, Miao C, Wei C, Ni M, Shen J, Li H, Yue J, Lu H, Fan B, Zhu H, Hu X, Kong FS, Yu J*, Yuan S*. Association of twice-daily radiotherapy with subsequent brain metastases in adults with small cell lung cancer. JAMA Netw Open. 2019 May 3;2(5): e190103.

22. Jiang A, Sun W, Zhao F, Wu Z, Shang D, Yu Q, Wang S, Zhu J, Yang F, Yuan S*. Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases. Radiation Oncology.2019 Mar 15;14(1):46.

23. Li L, Ma L, Shang D, Liu Z, Yu Q, Wang S, Teng X, Zhang Q, Hu X, Zhao W, Hou W, Jin J, Kong FS, Yu J, Yuan S*. Pretreatment PET/CT imaging of angiogenesis based on ¹⁸F-RGD tracer uptake may predict antiangiogenic response. Eur J Nucl Med Mol Imaging. 2019 Apr;46(4):940-947. 2019 Apr;46(4): 940-947.

• 本人承担科研项目：

• 本人成果获奖情况