• 研究组主要研究兴趣及方向：

长期从事生殖遗传与相关临床疾病的研究和临床应用，主要方向为不孕不育致病基因与突变的筛选与功能鉴定；基因组学、RNA组学、蛋白组学等在配子发生中的应用与分析；关键基因和小RNA在配子发育中的生物信息学分析和功能研究及在其辅助生殖技术中的临床应用。

• 个人简况：

1. 导师类型：科学学位硕士生导师

2. 专业技术职称：研究员

3. 行政职务：妇产科主任助理

4. 招生专业：妇产科学

5. 简介：

1983年10月出生。

 ①学术任职情况：

海峡两岸医药交流协会遗传与生殖专委会 委员；安徽细胞学会 理事；安徽细胞学会生殖遗传分会 秘书长；安徽生殖遗传专科联盟 秘书长；

 ②个人教育及工作经历：

2006/9–2012/6, 中国科学技术大学, 遗传学, 博士（硕博连读）, 导师:史庆华

• 联系方式：

E-mail:bio_xubo@163.com

电话：13856048699

• 近五年发表重要学术论文：

1. Ji J, Zhu X, Zhang Y, Shui L, Bai S, Huang L, Wang H, Fan S, Zhang Z, Luo L, Xu B^(#) . A Proteomic Analysis of Human Follicular Fluid: Proteomic Profile Associated with Embryo Quality. Reprod Sci. 2024 Jan;31(1):199-211.

2. Fan S, Wang Y, Jiang H, Jiang X, Zhou J, Jiao Y, Ye J, Xu Z, Wang Y, Xie X, Zhang H, Li Y, Liu W, Zhang X, Ma H, Shi B, Zhang Y, Zubair M, Shah W, Xu Z, Xu B^(#) , Shi Q^(#). A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation. Cell Discov. 2023 Aug 23;9(1):88.

3. Fan S, Zhao Y, Zhang Z, Wang H, Hou Y, Bai S, Liu R, Xu B^(#). Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross-sectional study. Health Sci Rep. 2023 Nov 8;6(11):e1683.

4. Hua J, Guo L, Yao Y, Hu W, Wan YY, Xu B^(#) Biallelic mutations in WDR12 are associated with male infertility with tapered-head sperm. Asian J Androl. 2023 May-Jun;25(3):398-403.

5. Hua J, Xu B^(*), Liu W, Shi J, Jiang H, Zha X, Zhang X, Wan Y. Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice. Hum Mol Genet. 2023 Apr 18:ddad061.

6. Bai S, Li Y, Hu MH, Wu L, Shui LJ, Wang XH, Liu YX, Yue QL, Yu LN, Fu KQ, Tong XH, Hu XC, Xu B^(#). Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility. Asian J Androl. 2021 Sep 21.

7. Bai S, Li Y, Wan Y, Guo T, Jin Q, Liu R, Tang W, Sang M, Tao Y, Xie B, Zhao Y, Li W, Xu X, Yue Q, Hu X, Xu B^(#). Sexually transmitted infections and semen quality from subfertile men with and without leukocytospermia. ReprodBiolEndocrinol. 2021 Jun 21;19(1):92.

8. Liu R, Bai S, Jiang X, Luo L, Tong X, Zheng S, Wang Y, Xu B^(#). Multifactor Prediction of Embryo Transfer Outcomes Based on a Machine Learning Algorithm. Front Endocrinol (Lausanne). 2021 Nov 2;12:745039.

9. Zong L, Zheng S, Meng Y, Tang W, Li D, Wang Z, Tong X, Xu B^(#) Integrated Transcriptomic Analysis of the miRNA–mRNA Interaction Network in Thin Endometrium. Front. Genet.  2021 12:589408.

10. Bai S, Hu X, Zhao Y, Li W, Wan Y, Jin R, Wang Y, Guo T, Tong X, Xu B^(#). Compound heterozygosity for novel AURKC mutations in an infertile man with macrozoospermia. Andrologia. 2020 Jun 1:e13663.

11. Hu MH, Zheng SX, Yin H, Zhu XY, Lu FT, Tong XH, Liu YS, Zhang YW, Xu B^(#). Identification of microRNAs that Regulate the MAPK Pathway in Human Cumulus Cells from PCOS Women with Insulin Resistance. Reprod Sci. 2020 Mar;27(3):833-844.

• 本人承担科研项目：

• 本人成果获奖情况