研究组主要研究兴趣及方向:
1. 肿瘤治疗抵制的机制探讨;
2. 肿瘤早期筛查分子标志物挖掘;
3. m6A修饰在肿瘤进展中的调控机制。
个人简况:
导师类型:科学学位硕士生导师
专业技术职称:副研究员/主管技师
行政职务:检验科主任助理
招生专业:临床检验诊断学
简介:
1986年1月。博士,副研究员,副教授,博士后指导老师,硕士生导师。现任中国科学技术大学附属第一医院检验科主任助理。安徽省教育厅杰出青年基金获得者,安徽省卫生健康委第一届骨干人才,中国科学技术大学附属第一医院第三批青年技术骨干。
①学术任职情况:
中国人体健康科技促进会临床检验科学技术转化专业委员会委员;
中国中西医结合学会检验医学专业委员会液态活检技术学组专家委员会委员;
中国检验医学青年教师科创联盟委员;
安徽省医师协会医学检验分会青年委员;
安徽省医学会微生物与免疫分会委员。
②个人教育及工作经历:
2005/09-2009/07,安徽医科大学,学士;
2009/09-2014/07,中山大学,硕博连读;
2014/08-至今,中国科大附属第一医院检验科,助理研究员/主管技师/副研究员
联系方式:
E-mail: demo@ustc.edu.cn
电话:0551-62282393
近五年发表重要学术论文:
Jimin Li#, Fang Yang#, Zeyu Wang, Siqing Zheng, Shuang Zhang, Chen Wang, Bing He, Jia-Bei Wang*, Hao Wang*. METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer. Cell Proliferation. 2023. e13590.(IF:8.5;中科院1区)
Wei-Wei Liu, Si-Qing Zheng, Tian Li, Yun-Fei Fei, Chen Wang, Shuang Zhang, Fei Wang*, Guan-Min Jiang*, Hao Wang*. RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy. Signal Transduction and Targeted Therapy. 2024. DOI: 10.1038/s41392-024-01777-5.(IF:39.3;中科院1区)
Wei Wei, ZhongYuan Zhang, Bin Shi, Yike Cai, HouShun Zhang, ChunLei Sun, YunFei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, GuanMin Jiang*, Hao Wang*. METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression. Journal of Experimental & Clinical Cancer Research. 2023. 42: 151.(IF:11.3;中科院1区)
Hao Wang, Wei Wei, Zhong-Yuan Zhan, Yao Liu, Bin Shi, Wen Zhong, Hou-Shun Zhan, Xin Fang, Chun-Lei Sun, Jia-Bei Wang*, Lian-Xin Liu*. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4. Cell Death & Disease. 2021, 13(1):3.(IF:9.685;中科院1区)
Bin Shi, WeiWei Liu, Ke Yang, GuanMin Jiang*, Hao Wang*. The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer. Molecular cancer. 2022. 21(1):163.(IF:37.3;中科院1区)
Hao Wang, Ji-Min Li, Wei Wei, Rui Yang, Dong Chen, Xiao-Dong Ma*, Guan-Min Jiang*, Bao-Long Wang*. Regulation of ATP-binding cassette subfamily B member 1 by Snail contributes to chemo-resistance in colorectal cancer. Cancer Science. 2020. 111:84–97.(IF:6.716;中科院2区)
WeiWei Liu, ZhongYuan Zhang, Fei Wang*, Hao Wang*. Emerging roles of m6A RNA modification in cancer therapeutic resistance. Experimental Hematology & Oncology. 2023.12.21.(IF:10.9;中科院2区)
Feng Shu, Han Xiao, Qiu-Nuo Li, Xiao-Shuai Ren, Zhi-Gang Liu, Bo-Wen Hu, Hong-Sheng Wang*, Hao Wang*, Guan-Min Jiang*. Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets. Signal Transduction and Targeted Therapy. 2023. 8:32.(IF:39.3;中科院1区)
本人承担科研项目:
项目名称、来源 | 起止时间 | 总经费(万元) |
m6A甲基化修饰调控结直肠癌恶性进展研究。安徽省教育厅杰出青年项目(2022AH020079) | 2023/01-2025/12 | 100 |
安徽省高校杰出青年科研项目(2022AH020079):m6A甲基化修饰调控结直肠癌恶性进展研究 | 2023/01-2025/12 |