蔡娟








  • 研究组主要研究兴趣及方向

1. 消化道肿瘤免疫逃逸机制;

2. 肿瘤代谢与免疫治疗;

3. 肿瘤纳米载药递送。


  • 个人简况:

  1. 导师类型:专业学位硕士生导师

  2. 专业技术职称:副主任医师

  3. 行政职务:消化道肿瘤内科亚专科副主任,病区主任

  4. 招生专业:肿瘤学

  5. 简介:

19871月出生

 ①学术任职情况:

中国抗癌协会支持治疗专业委员会委员;

安徽省抗癌协会肿瘤整体评估专业委员会副主任委员;

安徽省临床肿瘤学会转化医学专业委员会常委。

 ②个人教育及工作经历:

教育经历:

12016/09-2019/06, 南京医科大学, 肿瘤学, 博士。

22009/09-2012/06, 华中科技大学, 肿瘤学, 硕士。

工作经历:

12022.12-2024.7,皖南医学院附属弋矶山医院,肿瘤内科,副主任医师

22024.07-至今,中国科学技术大学附属第一医院,消化道肿瘤内科,副主任医师


  • 联系方式:

E-mail: caijuan1987@ustc.edu.cn

电话:18375330952


  • 近五年发表重要学术论文:(不超过8篇)

  1. Runyu Dong#; Yao Fei#; Yiren He#; Peng Gao#; Bo Zhang; Menglin Zhu; Zhixiong Wang; LongfeiWu; Shuai Wu; Xiaoming Wang; Juan Cai*; Zhiqiang Chen*; Xueliang Zuo*; Lactylation-driven HECTD2limits the response of hepatocellular carcinoma to lenvatinib, Advanced Science, 2025,2412559.(中科院一区IF = 14.3)

  2. Xueliang Zuo#; Zhiqiang Chen#; Wen Gao#; Yao Zhang; Jinguo Wang; Junfeng Wang; Ming Cao; Juan Cai*; Jindao Wu*; Xuehao Wang*; M6A-mediated Upregulation of LINC00958 Increases Lipogenesisand Acts as a Nanotherapeutic Target in Hepatocellular Carcinoma, Journal of Hematology &Oncology, 2020, 13(1): 5.(中科院一区IF = 29.5ESI高被引论文)

  3. Yanna Li#; Zhixiong Wang#; Peng Gao#; Danping Cao#; Runyu Dong; Menglin Zhu; Yao Fei;Xueliang Zuo*; Juan Cai*; CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and actsas a nanotherapeutic target in gastric cancer, Journal of Translational Medicine, 2024, 22(1):704.(中科院二区IF = 7.400)

  4. Juan Cai#; Zhiqiang Chen#; Yao Zhang; Jinguo Wang; Zhengrong Zhang; Jindao Wu; Jiading Mao*;Xueliang Zuo*; CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy viam6A modification in hepatocellular carcinoma, Molecular Therapy - Oncolytics, 2022, 24: 755-771.(中科院二区IF = 7.200)

  5. Juan Cai#; Zhiqiang Chen#; Jinguo Wang; Junfeng Wang; Xianjun Chen; Linhu Liang; Min Huang;Zhengrong Zhang; Xueliang Zuo*; circHECTD1 facilitates glutaminolysis to promote gastric cancerprogression by targeting miR-1256 and activating β-catenin/c-Myc signaling, Cell Death &Disease, 2019, 10(8): 576. (中科院一区IF = 9.685)

  6. Yao Fei#; Danping Cao#; Yanna Li#; Zhixiong Wang; Runyu Dong; Menglin Zhu; Peng Gao; Xiaoming Wang; Juan Cai*; Xueliang Zuo*; Circ_0008315 promotes tumorigenesis and cisplatin resistance and acts as a nanotherapeutic target in gastric cancer, Journal of Nanobiotechnology, 2024, 22(1): 519. (中科院一区IF = 10.6)

  7. Zhixiong Wang#; Menglin Zhu#; Runyu Dong; Danping Cao; Yanna Li; Zhiqiang Chen; Juan Cai*; Xueliang Zuo*; TH-302-loaded nanodrug reshapes the hypoxic tumour microenvironment and enhances PD-1 blockade efficacy in gastric cancer, Journal of Nanobiotechnology, 2023, 21(1): 440. (中科院一区IF = 10.6)

  8. Yao Fei#, Danping Cao#, Runyu Dong, Yanna Li, Zhixiong Wang, Peng Gao, Menglin Zhu, Xiaoming Wang, Xueliang Zuo*, Juan Cai*. The cuproptosis-related gene UBE2D2 functions as an immunotherapeutic and prognostic biomarker in pan-cancer. Clinical & Translational Oncology, 2024, 26(10):2718-2737.

  • 本人承担在研科研项目:

    项目名称、来源

    起止时间

    总经费(万元)

    METTL16介导CTNNB1 m6A修饰上调PD-L1表达促进胃癌免疫逃逸的作用及机制研究。国家自然科学基金面上项目

    2024/01-2027/12

    49

    基于CRISPR/CAS9文库筛选缺氧微环境下胃癌免疫逃逸的作用及机制研究。安徽省教育厅优秀青年科学基金

    2022/01-2025/12

    50

  • 本人成果获奖情况

获奖名称

颁奖部门

获奖等级

本人排名

获奖时间

安徽省自然科学奖

安徽省人民政府

省部级

2

2025.1